#5: Marlo Thomas, That Girl (1966–1971)
Right from the pilot episode, Marlo Thomas gave That Girl a breezy, modern energy as aspiring actress Ann Marie. The show followed her attempts to make it in New York while juggling auditions, roommates, and a sometimes skeptical boyfriend. Ann’s independence and charm made her a relatable, fashionable icon for young viewers.

Beyond That Girl, Thomas built a remarkably varied career as an actress, producer, and activist. She became closely associated with St. Jude Children’s Research Hospital through her father Danny Thomas and later her own advocacy. Her career expanded into books, television specials, and philanthropy, cementing her legacy far beyond sitcom fame.
